What to do when the biggest player doesn't want to talk to you?

If the market leader won't talk to you, try the runner up. The second place player usually has a very clear goal--get to first place--and they will be considerably more open to taking a chance with you. 

This works especially well when the second place player is small compared to number one but still big in absolute terms. You still get an important partnership, and by helping them grow you also grow yourself.